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Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
Immune system problems last up to 8 months after mild to moderate COVID-19 infection
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Abstract
Patients with long COVID exhibited a 78.5-81.6% accuracy in associating specific inflammatory mediators with their condition.
- A significant proportion of individuals recovering from COVID-19 experience long COVID symptoms lasting over 12 weeks.
- Individuals with long COVID displayed highly activated innate immune cells and a deficiency of naive T and B cells.
- Elevated levels of type I IFN (IFN-β) and type III IFN (IFN-λ1) were observed, remaining persistently high up to 8 months post-infection.
- An optimal set of 28 analytes was identified for strong association with long COVID symptoms using a log-linear classification model.
- Key inflammatory mediators associated with long COVID included IFN-β, PTX3, IFN-γ, IFN-λ2/3, and IL-6.
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