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Abstract
Chronic neuroinflammation is a key mechanism in Alzheimer's disease, linking genetic and metabolic dysfunctions.
- Alzheimer's disease is characterized by cognitive decline and the presence of amyloid-β plaques and neurofibrillary tangles.
- Activated immune cells, such as microglia and astrocytes, release inflammatory substances that worsen neuronal damage.
- Impaired mechanisms for clearing waste and disruptions in the blood-brain barrier contribute to sustained neuroinflammation.
- Dysregulation of various metabolic pathways, including those for glucose and lipids, is associated with an inflammatory state in Alzheimer's.
- Genetic variants, such as APOE4 and TREM2, influence how microglia manage lipids and respond to inflammation.
- Natural compounds like polyphenols may help regulate immune and metabolic pathways, potentially offering new therapeutic strategies.
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