Neuroinflammation and immunometabolism in neurodegenerative diseases

Feb 12, 2025Current opinion in neurology

Brain Inflammation and Immune Cell Metabolism in Brain Degeneration Diseases

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Abstract

Microglia exhibit high metabolic flexibility and can utilize various nutrients for their functions.

  • Microglia can change their metabolic processes in response to immune triggers and inflammatory conditions.
  • Altered metabolism in microglia is associated with neuroinflammation and may play a role in diseases like Alzheimer's.
  • Recent studies have identified connections between metabolic changes in microglia and risk genes linked to neurodegenerative diseases.
  • Understanding these metabolic dysregulations in microglia could reveal new targets for treatment.

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