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Circadian rhythm, microglia-mediated neuroinflammation, and Alzheimer’s disease
Daily Body Clock, Brain Immune Cells, and Alzheimer's Disease
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Abstract
Microglia are key mediators of neuroinflammation and may be influenced by circadian rhythms.
- Microglia respond to immune pathogens and toxins, playing a role in clearing debris and regulating brain function.
- They are involved in phagocytosing amyloid-β plaques, which are linked to Alzheimer's disease.
- Circadian clock genes are associated with the regulation of microglial functions, including phagocytosis.
- Disruption of circadian rhythms may correlate with the progression of Alzheimer's disease.
- Potential therapeutic targets include hormone modulation and lifestyle interventions to support brain health.
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