How a modified sugar from P. parvulus 2.6 affects human immune cells called macrophages and myeloid cells

Purified 2-substituted (1-3)-β-D-glucan activates macrophages and exhibits an anti-inflammatory effect.

• Macrophages are immune cells that play a crucial role in the body's response to pathogens.
• The study focused on the effects of β-glucans produced by specific microorganisms on macrophage activity.
• PMA-differentiated THP-1 cells and M1 pro-inflammatory monocyte-derived macrophages were used to assess these effects.
• The findings suggest that this particular β-D-glucan could enhance macrophage activation.
• An anti-inflammatory response was observed in macrophages treated with the β-D-glucan.

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