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Abstract
Immunosenescence is associated with a decline in immune function that may contribute to age-related diseases.
- Aging is linked to various changes in the immune system, including loss of naïve T cells and reduced diversity in T cell receptors.
- The accumulation of senescent T cells and impaired regulatory T cell function may drive chronic inflammation and tissue damage in autoimmune and metabolic diseases.
- In neurodegenerative diseases, aging of microglia and persistent neuroinflammation could worsen neuronal loss.
- Immunosenescence may serve as a common mechanism connecting aging with both systemic and organ-specific health issues.
- Recent advances in biomarker discovery allow for the quantitative assessment of immune aging.
- Emerging therapeutic strategies, such as cytokine modulation and senolytics, could help restore immune function.
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