Full text is available at the source.
Abstract
Immunosenescence and inflammaging may affect the efficacy of anti-cancer immunotherapy in older patients.
- Aging is associated with a decrease in the immune system's ability to respond effectively due to immunosenescence.
- Higher levels of differentiated T cells and lower levels of naive T cells are observed with advancing age.
- The incidence and prevalence of cancers increase with age, potentially due to decreased immunosurveillance.
- Inflammaging contributes to a low-grade proinflammatory state characterized by elevated inflammatory mediators.
- Current T-cell targeted therapies, including bispecific T cell engagers and CAR-T cells, may be influenced by the aging immune system.
- Further research on immunosenescence biomarkers is needed to develop safer and more effective therapies.
Simplified