The Role of Immunosenescence in the Development of Age-Related Diseases.

Apr 23, 2016Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

How Aging of the Immune System May Contribute to Age-Related Diseases

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Abstract

Immunosenescence is associated with low-grade inflammation known as inflammaging.

Immunosenescence involves changes in both the innate and adaptive immune systems.
Aging may contribute to chronic diseases such as cardiovascular diseases, neurodegenerative diseases, cancer, and type 2 diabetes through inflammaging.
The exact origin of inflammaging remains uncertain but may involve factors like immune response changes and chronic stimulation.
Senescent cells, which have a specific secretory profile, may play a role in the process of inflammaging.

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Aging is a complex phenomenon leading to numerous changes in the physiological systems of the body. One of the most important changes, called immunosenescence, occurs in the immune system. Immunosenescence covers changes in the innate and the adaptive immune systems and is associated with a low-grade inflammation called inflammaging. Aging, likely via inflammaging, is also associated with the emergence of chronic diseases including cardiovascular and neurodegenerative diseases, cancer, and diabetes mellitus type 2. The origin of this inflammaging is not known with certainty, but several concurrent contributing factors have been suggested, such as aging-associated changes in the innate and adaptive immune response, chronic antigenic stimulation, the appearance of endogenous macromolecular changes, and the presence of senescent cells exhibiting a senescence-associated secretory phenotype. A better understanding of the multiple biological phenomena leading to these diseases via the immunosenescence associated with inflammaging provides a powerful target for interventions to increase the healthspan of elderly subjects.

The Role of Immunosenescence in the Development of Age-Related Diseases.

Abstract

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