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Immune senescence, epigenetics and autoimmunity
Aging of the immune system, gene regulation changes, and autoimmune diseases
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Abstract
Aging is associated with a decline in both adaptive and innate immune responses.
- Aging may lead to chronic inflammation, termed 'inflammaging.'
- There is an increased likelihood of developing autoimmune diseases with age.
- Epigenetic changes in immune cells may contribute to the observed inflammation and autoimmunity.
- Environmental factors are suggested to influence these epigenetic changes in both dividing and non-dividing cells.
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