Immune response features in older adults and autoimmune conditions

Aging is associated with diminished immune response, increased pro-inflammatory mediators, and a higher risk of autoimmunity.

• Immunosenescence involves decreased effectiveness of the immune system against infections.
• Elevated levels of pro-inflammatory substances contribute to chronic low-grade inflammation, known as inflammaging.
• This chronic inflammation may lead to an increased occurrence of chronic diseases as people age.
• Autoantibodies are frequently detected in elderly individuals, indicating a potential rise in autoimmune conditions.
• Certain autoimmune diseases may manifest for the first time in older adults, influenced by changes in immune function.

Simplified