[Characteristics of immune response in elderly and autoimmunity.].

Aging is associated with diminished immune response, increased pro-inflammatory mediators, and a higher risk of autoimmunity.

• Immunosenescence involves decreased effectiveness of the immune system against infections.
• Elevated levels of pro-inflammatory substances contribute to chronic low-grade inflammation, known as inflammaging.
• This chronic inflammation may lead to an increased occurrence of chronic diseases as people age.
• Autoantibodies are frequently detected in elderly individuals, indicating a potential rise in autoimmune conditions.
• Certain autoimmune diseases may manifest for the first time in older adults, influenced by changes in immune function.

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