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From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation
How Aging May Weaken the Immune System from Chronic Inflammation to Reduced Response
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Abstract
Aging is associated with a decrease in immune functions and an increase in pro-inflammatory activity.
- Immunosenescence refers to the decline in immune function due to aging.
- Some immune cells, particularly monocytes and macrophages, may exhibit increased pro-inflammatory activity with age.
- Trained immunity, supported by epigenetic changes, allows innate immune cells to retain a form of memory after exposure to stressors.
- The relationship between inflamm-aging and immunosenescence may lead to increased inflammation alongside decreased immune responses.
- These changes could create a heightened state of immune alertness, potentially resulting in inflammatory diseases associated with aging.
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