Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions

Apr 9, 2026BMC medicine

Understanding and treating aging-related immune decline in lung diseases

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Abstract

Immunosenescence is associated with the pathogenesis and progression of lung diseases.

  • Age-related decline in immune function may contribute to various lung diseases, including COPD, lung cancer, and asthma.
  • Current therapeutic strategies evaluated in clinical trials include senolytics, immunotherapy, and stem cell therapy.
  • Personalized approaches utilizing multi-omics data and artificial intelligence could enhance biomarker-driven interventions.
  • Rigorously designed clinical trials are essential for developing and validating interventions targeting immunosenescence.

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