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Importance of Gut Microbiota Dysbiosis and Circadian Disruption–Associated Biomarkers in Emergence of Alzheimer’s Disease
Links Between Gut Bacteria Imbalance, Body Clock Disruption, and Early Signs of Alzheimer's Disease
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Abstract
Gut-derived metabolites like calprotectin and trimethylamine-N-oxide may play a key role in the pathogenesis of Alzheimer's disease (AD).
- Gut dysbiosis is characterized by imbalanced gut microbiota and compromised intestinal integrity, which can lead to the entry of bacterial metabolites into the bloodstream.
- Circadian disruption is associated with increased accumulation of amyloid-beta and tau proteins, which are linked to AD progression.
- Circadian dysregulation may contribute to the development of gut dysbiosis.
- Potential biomarkers related to gut dysbiosis and circadian disruption were identified in preclinical and clinical studies of AD.
- Understanding the relationship between the microbiota-gut-brain axis and circadian rhythms could assist in the early diagnosis of AD and the creation of targeted therapies.
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