Gut microbiota in Alzheimer’s disease: Understanding molecular pathways and potential therapeutic perspectives

Gut microbiota may play a crucial role in Alzheimer's disease pathogenesis and progression.

• Dysbiosis of gut microbiota may compromise intestinal barrier integrity, allowing harmful molecules to enter the bloodstream and brain.
• The production of short-chain fatty acids, secondary bile acids, and tryptophan metabolites by gut microbiota could influence the risk of Alzheimer's disease.
• The vagus nerve may facilitate communication between the gut and brain, impacting Alzheimer's disease.
• While preclinical studies indicate potential benefits of targeting gut microbiota for Alzheimer's treatment, clinical evidence is limited and inconsistent.
• There is a need for further research to clarify the exact molecular mechanisms linking gut microbiota to Alzheimer's disease.

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