Impulsivity and aggressiveness in bipolar disorder with co-morbid borderline personality disorder

Dec 7, 2010Psychiatry research

Impulsivity and aggression in bipolar disorder with borderline personality disorder

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Abstract

Patients with co-morbid bipolar disorder and borderline personality disorder exhibited three times higher rates of attempted suicides compared to those with bipolar disorder alone.

A total of 57 patients were evaluated, including 18 with co-morbid bipolar disorder and borderline personality disorder.
Mean impulsivity and aggressivity scores were significantly higher in patients with both bipolar disorder and borderline personality disorder compared to those with bipolar disorder alone or with other personality disorders.
The rate of attempted suicides was approximately 7.6 times higher in patients with co-morbid bipolar disorder and borderline personality disorder compared to those with bipolar disorder and other personality disorders.
The findings suggest that co-morbid borderline personality disorder may increase impulsivity and aggressivity in patients with bipolar disorder.
This co-morbid condition is associated with an increased risk of suicidality.

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Few studies to date have been performed to investigate impulsivity and aggressivity in patients with bipolar disorder (BD) and borderline personality disorder (BPD); the primary aim of the present study was to evaluate the impact of co-morbidity of BPD on impulsivity and aggressivity in patients affected by BD. A total of 57 patients (male=20, female=37) affected by BD (BD-I 51%; BD-II 49%) in clinical stable remission were recruited; 28 patients were affected by BD (49.1%), 18 by BD and BPD (31.6%) and 11 (19.3%) by BD plus other personality disorders (OPD) (19.3%). They were assessed with the Structured Clinical Interview for DSM-IV (SCID)-I and SCID-II, and were evaluated by means of the Clinical Global Impression (CGI)-severity and Global Assessment Functioning (GAF) scales, the Barratt Impulsivity Scale (BIS-11) and the Aggression Questionnaire (AQ). Mean total scores were significantly higher among BD/BPD patients with respect to BD and to BD/OPD, both on the BIS-11 and the AQ; the rate of attempted suicides was approximately three times higher in BD/BPD patients with respect to BD and 7.6 times higher than in BD/OPD patients. The results of our study suggest that patients with co-morbid BD and BPD are more impulsive and aggressive. Furthermore, this co-morbid condition may be a risk factor for suicidality.

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Impulsivity and aggressiveness in bipolar disorder with co-morbid borderline personality disorder

Abstract

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