Comparison of the Effects of Inappropriate Meal Timing-Induced and Genetic Models of Circadian Clock Disruption on Uterine mRNA Expression Profiles

A total of 516 genes were significantly affected by a 28-h feeding cycle model compared to 346 genes influenced by a core clock gene knockout model.

• The 28-h feeding cycle resulted in 4-fold changes in gene expression, while the Bmal1 knockout led to 2-fold changes.
• Only 7 genes from the 28-h cycle were similarly regulated in the Bmal1 knockout model, indicating distinct regulatory effects.
• A majority of the genes affected (n = 44, 62.9%) in both models were oppositely regulated.
• Gene set enrichment analyses confirmed the differences in gene expression profiles between the two models.
• These findings suggest that meal timing and genetic disruption of circadian rhythms may have different impacts on gene expression.

AI simplified