Association between index-to-ring finger length ratio and risk of severe knee and hip osteoarthritis requiring total joint replacement

Over an average of 10.5 years, 580 participants underwent total knee replacement due to severe knee osteoarthritis (OA).

• A greater right 2D:4D finger length ratio is associated with a reduced incidence of total knee replacement.
• The hazard ratio for a standard deviation increase in right 2D:4D is 0.91, suggesting a lower risk of knee replacement.
• Similar associations were found for the average of both right and left 2D:4D measurements.
• No significant associations were observed between 2D:4D and the incidence of total hip replacement.
• A lower 2D:4D may indicate a higher risk of severe knee OA requiring surgery.

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