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Abstract
Most older individuals develop inflammageing, characterized by elevated blood inflammatory markers linked to chronic morbidity and premature death.
- Inflammageing is associated with increased susceptibility to chronic conditions such as cardiovascular diseases, chronic kidney disease, diabetes, cancer, depression, dementia, and sarcopenia.
- Potential mechanisms contributing to inflammageing include genetic factors, central obesity, changes in gut health, and immune system dysregulation.
- The relationship between inflammation and cardiovascular diseases is suggested to be causal based on clinical trial evidence.
- The impact of inflammation on non-cardiovascular health issues remains uncertain and requires further investigation.
- There is a need for clinical trials to test if early intervention in inflammageing can prevent or delay cardiovascular frailty.
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