Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease

Jun 30, 2023Journal of the American College of Cardiology

How Aging Science May Influence Treatments for Heart Disease in Older Adults

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Abstract

Geroscience suggests that cardiovascular disease (CVD) may stem from a decline in mechanisms that counteract age-related molecular damage.

Cardiovascular disease is often linked to multimorbidity and frailty in older patients.
Aging negatively impacts prognosis and treatment responses for CVD.
Resilience mechanisms in aging may influence the development and progression of CVD.
Gerotherapeutics aim to enhance these resilience mechanisms to prevent chronic diseases and improve overall healthspan.
Some gerotherapeutic strategies are already being utilized in CVD management, indicating their potential to transform patient care.

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Geroscience posits that cardiovascular disease (CVD) and other chronic diseases result from progressive erosion of the effectiveness of homeostatic mechanisms that oppose age-related accumulation of molecular damage. This hypothetical common root to chronic diseases explains why patients with CVD are often affected by multimorbidity and frailty and why older age negatively affects CVD prognosis and treatment response. Gerotherapeutics enhance resilience mechanisms that counter age-related molecular damage to prevent chronic diseases, frailty, and disability, thereby extending healthspan. Here, we describe the main resilience mechanisms of mammalian aging, with a focus on how they can affect CVD pathophysiology. We next present novel gerotherapeutic approaches, some of which are already used in management of CVD, and explore their potential to transform care and management of CVD. The geroscience paradigm is gaining traction broadly in medical specialties, with potential to mitigate premature aging, reduce health care disparities, and improve population healthspan.

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Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease

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