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Abstract
Geroscience explores how molecular mechanisms drive aging and its associated diseases.
- Gerotherapeutics aim to counteract molecular drivers of aging to reduce chronic diseases and geriatric syndromes.
- Concerns about safety and valid endpoints have delayed the prescription of potentially harmful medications to healthy older adults.
- Trials of gerotherapeutic medications are more readily implemented when their benefits outweigh the risks associated with treating diseases.
- Metrics for effective disease treatments are often considered more reliable than those for prolonging health.
- Clarifying the mechanisms of geroscience in therapeutic contexts may enhance the advancement of translational geroscience.
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