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Improvement of the inflammation-damaged intestinal barrier and modulation of the gut microbiota in ulcerative colitis after FMT in the SHIME® model
Improving a damaged gut lining and changing gut bacteria in ulcerative colitis after fecal transplant in a lab model
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Abstract
(FMT) increased microbial diversity and butyrate levels in the gut microbiota of ulcerative colitis patients.
- FMT was associated with a significant increase in total bacteria, Bacteroidota, and Lactobacillus in the gut microbiota.
- The relative abundance of beneficial species such as Faecalibacterium prausnitzii and Bifidobacterium longum increased following FMT.
- New species including Blautia obeum and Roseburia faecis were enriched in the microbiota after FMT.
- Microbial metabolites modified by FMT were found to prevent intestinal barrier damage and reduce inflammation markers in vitro.
- A single dose of FMT enhanced the composition and metabolic activity of the microbiota in a simulated environment.
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Key numbers
27
Increase in Total Bacteria
Total bacterial taxa increased from 15 to 27 after treatment.
3.5% → 16.1%
Butyrate Level Increase
Butyrate levels rose significantly after in the UC microbiota.
IL-8 < 0.001
Decrease in IL-8 Secretion
IL-8 secretion was significantly inhibited following treatment.