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Application of an Injectable Thermosensitive Hydrogel Drug Delivery System for Degenerated Intervertebral Disc Regeneration
Injectable Temperature-Activated Gel for Repairing Damaged Spinal Discs
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Abstract
An injectable hydrogel system effectively delivers the anti-inflammatory drugs tannic acid and resveratrol to degenerated intervertebral discs.
- This hydrogel system is designed to provide local and sustained drug delivery.
- Tannic acid is delivered directly, while resveratrol is delivered indirectly via inflammation-responsive nanoparticles.
- In vitro and in vivo tests indicate that the hydrogel system may reduce inflammation in degenerated intervertebral discs.
- The system is associated with promoting the regeneration of the extracellular matrix in the nucleus pulposus.
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