The pathogenic role of innate lymphoid cells in autoimmune-related and inflammatory skin diseases

Mar 24, 2020Cellular & molecular immunology

How innate immune cells may contribute to autoimmune and inflammatory skin diseases

AI simplified

Abstract

Innate lymphoid cells (ILCs) play key roles in the immune response and are involved in maintaining metabolic balance and regulating tissue inflammation.

ILCs develop from a common lymphoid progenitor and are found in various tissues such as the intestine, skin, and lungs.
Distinct subsets of ILCs are implicated in local immunity and can influence both adaptive immunity and inflammatory responses.
Recent findings link ILCs to the pathogenesis of autoimmune skin diseases like systemic lupus erythematosus and psoriasis.
Further studies are necessary to clarify how ILCs regulate their functions and interact with other immune cells in inflammatory conditions.

AI simplified

Innate lymphoid cells (ILCs), as an important component of the innate immune system, arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues, including the intestine, skin, lung, and adipose tissue. ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orchestrating immune response and contribute to maintain metabolic homeostasis and regulate tissue inflammation. Currently, more details about the pathways for the development and differentiation of ILCs have largely been elucidated, and cytokine secretion and downstream immune cell responses in disease pathogenesis have been reported. Recent research has identified that several distinct subsets of ILCs at skin barriers are involved in the complex regulatory network in local immunity, potentiating adaptive immunity and the inflammatory response. Of note, additional studies that assess the effects of ILCs are required to better define how ILCs regulate their development and functions and how they interact with other immune cells in autoimmune-related and inflammatory skin disorders. In this review, we will distill recent research progress in ILC biology, abnormal functions and potential pathogenic mechanisms in autoimmune-related skin diseases, including systemic lupus erythematosus (SLE), scleroderma and inflammatory diseases, as well as psoriasis and atopic dermatitis (AD), thereby giving a comprehensive review of the diversity and plasticity of ILCs and their unique functions in disease conditions with the aim to provide new insights into molecular diagnosis and suggest potential value in immunotherapy.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text (HTML) ↗

Abstract

Full Text

Related papers

what lands in your inbox each week: