Psychiatry research

Changes in insomnia symptoms during early treatment of major depression

Updated

Abstract

In a study of 180 patients, remitters of major depressive disorder had significantly lower insomnia scores throughout 8 weeks of treatment with escitalopram.

  • Remission of depression was associated with lower scores for sleep-onset and mid-nocturnal insomnia as measured by the Quick Inventory Depressive Scale.
  • Remitters also had significantly better sleep quality scores as assessed by the Pittsburgh Sleep Quality Index.
  • The findings suggest that monitoring insomnia symptoms may be useful for predicting acute remission of depression during treatment.

Simplified

Full Text

Full text is available at the source.

Funding

Competing interests

Declaration of Competing Interest MD, MW, VKT, ID, and WL do not have any disclosures. BNF has received grant/research support from Alternative Funding Plan Innovations Award, Brain and Behavior Research Foundation, Canadian Institutes of Health Research, Hamilton Health Sciences Foundation, J.P. Bickell Foundation, Ontario Brain Institute, Ontario Mental Health Foundation, Society for Women's Health Research, Teresa Cascioli Charitable Foundation, Eli Lilly and Pfizer, and has received consultant and/or speaker fees from AstraZeneca, Bristol-Myers Squibb, Canadian Psychiatric Association, CANMAT, Daiichi Sankyo, Lundbeck, Pfizer, Servier and Sunovion. RVM has received consulting and speaking honoraria from AbbVie, Allergan, Janssen, KYE, Lundbeck, Otsuka, and Sunovion, and research grants from CAN-BIND, CIHR, Janssen, Lallemand, Lundbeck, Nubiyota, OBI and OMHF. AVR has received speaker and consultant honoraria or research funds from Bristol Myers Squibb, Canadian Depression Research and Intervention Network, Canadian Foundation for Innovation and the Ministry of Economic Development and Innovation, Canadian Institutes of Health Research, Grand Challenges Canada, Janssen, Lundbeck, Ontario Mental Health Foundation, Pfizer and Sunovion. SVP has been a consultant to Takeda, Bristol Myers Squibb, Lundbeck; has had a research contract with Assurex; has equity in Mensante. SR holds a patent ‘Teneurin C-Terminal Associated Peptides (TCAP) and methods and uses thereof.’ Inventors: David Lovejoy, R.B. Chewpoy, Dalia Barsyte, Susan Rotzinger. RWL has received speaker and consultant honoraria or research funds from AstraZeneca, Brain Canada, Bristol-Myers Squibb, the Canadian Institutes of Health Research (CIHR), the Canadian Network for Mood and Anxiety Treatments, the Canadian Psychiatric Association, Eli Lilly, Janssen, Lundbeck, Lundbeck Institute, Medscape, Otsuka, Pfizer, Servier, St. Jude Medical, Takeda, the University Health Network Foundation, and Vancouver Coastal Health Research Institute. SHK has received honoraria or research funds from Abbott, Alkermes, Allergan, Boehringer Ingelheim, Brain Canada, CIHR, Janssen, Lundbeck, Lundbeck Institute, Ontario Brain Institute, Ontario Research Fund, Otsuka, Pfizer, Servier, Sunovion, Sun Pharmaceuticals, and holds stock in Field Trip Health. VB is supported by an Academic Scholar Award from the University of Toronto Department of Psychiatry and has received research support from the Canadian Institutes of Health Research, Brain & Behavior Foundation, Ontario Ministry of Health Innovation Funds, Royal College of Physicians and Surgeons of Canada, Department of National Defence (Government of Canada), New Frontiers in Research Fund, Associated Medical Services Inc. Healthcare, American Foundation for Suicide Prevention, Roche Canada, Novartis, and Eisai.
PubMed

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free