The integrated stress response in budding yeast lifespan extension

Nov 24, 2017Microbial cell (Graz, Austria)

How the stress response may help extend lifespan in budding yeast

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Longevity & Aging on OpenScience ↗PubMed ↗DOI ↗

Abstract

Virtually all means to experimentally extend lifespan in yeast result in the induction of cellular stress responses.

Aging involves gradual molecular changes that decline normal physiological functions over time.
Understanding the causes of aging is essential for developing therapies to extend lifespan and reduce age-related diseases.
The budding yeast Saccharomyces cerevisiae has been key in identifying conserved factors related to aging.
Evidence suggests that activation of the integrated stress response plays a significant role in extending lifespan in yeast.
These findings highlight the potential of yeast as a model for uncovering mechanisms that could inform human lifespan extension.

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Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion. The ultimate goal of aging research is to develop therapeutic means to extend human lifespan, while reducing susceptibility to many age-related diseases including cancer, as well as metabolic, cardiovascular and neurodegenerative disorders. However, this first requires elucidation of the causes of aging, which has been greatly facilitated by the use of model organisms. In particular, the budding yeast Saccharomyces cerevisiae has been invaluable in the identification of conserved molecular and cellular determinants of aging and for the development of approaches to manipulate these aging determinants to extend lifespan. Strikingly, where examined, virtually all means to experimentally extend lifespan result in the induction of cellular stress responses. This review describes growing evidence in yeast that activation of the integrated stress response contributes significantly to lifespan extension. These findings demonstrate that yeast remains a powerful model system for elucidating conserved mechanisms to achieve lifespan extension that are likely to drive therapeutic approaches to extend human lifespan and healthspan.

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The integrated stress response in budding yeast lifespan extension

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