Integrative genome-scale analysis of immune infiltration in esophageal carcinoma

Infiltration I had low immune cell presence and higher mutation load, while Infiltration II showed enrichment of cytotoxic T cells.

• A total of 78 ESCC patient datasets were analyzed for immune cell infiltration.
• Infiltration I exhibited low levels of immune cells and immunomodulators, alongside a higher mutation load.
• Infiltration II was characterized by a higher presence of cytotoxic T cells and immunosuppressive cells.
• Infiltration II also displayed increased levels of immune cytokines such as IFN-γ, TNF-β, and PD-L1.
• The infiltration group served as an independent predictor of prognosis, with a hazard ratio of 2.73.
• Results were confirmed in an additional dataset of 98 samples from the Gene Expression Omnibus database.

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