increased by 2.3±1.9 seconds in the intense pulsed light (IPL) treatment group compared to 0.5±1.4 seconds in the control group.
Both treatment methods resulted in improvements in dry eye disease (DED) symptoms.
The IPL arm showed a greater reduction in symptom severity, with a 38% reduction in SPEED compared to 22% in the control arm.
improved by 197% in the IPL arm versus a 96% improvement in the control arm.
Corneal fluorescein staining decreased significantly in both groups, but the difference was not statistically significant.
A composite score of lid margin abnormalities improved more in the IPL arm, indicating better overall treatment efficacy.
Simplified
OBJECTIVES: To compare the efficacy of intense pulsed light (IPL) combined with Meibomian gland expression (MGX), and instant warm compresses combined with MGX, for treatment of dry eye disease (DED) due to meibomian gland dysfunction (MGD).
METHODS: In a prospective, multicenter, interventional study, 120 subjects with DED due to MGD were randomized 1:1 to an IPL arm or a control arm. Each subject was treated 3 times at 3-week intervals. The primary outcome measure was the (TBUT). Tear break up time and a few additional outcome measures were evaluated at the baseline and at 3 weeks after the last treatment.
RESULTS: All outcome measures improved in both arms, but in general, the improvement was significantly larger in the IPL arm. Tear break up time increased by 2.3±1.9 and 0.5±1.4 sec, in the IPL and control arms respectively (P<0.001). SPEED was reduced by 38% and 22% in the IPL and control arms, respectively (P<0.01). was improved by 197% in the IPL arm and 96% in the control arm. Corneal fluorescein staining also decreased by 51% and 24% in the IPL and control arms respectively, but the differences between the two arms were not statistically significant (P=0.61). A composite score of lid margin abnormalities improved in both arms, but more in the IPL arm (P<0.05).
CONCLUSIONS: Intense pulsed light combined with MGX therapy was significantly more effective than instant warm compresses followed with MGX. This suggests that the IPL component has a genuine contribution to the improvement of signs and symptoms of DED.
Key numbers
2.3±1.9 sec
Increase in
increased from baseline to follow-up in the IPL arm.
38%
Decrease in
Percentage change from baseline to follow-up in the IPL arm.
197%
Improvement in
Percentage change in from baseline to follow-up in the IPL arm.
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