[Comparison of the effects of intensified lifestyle and glucagon-like peptide-1 receptor agonist combined with lifestyle intervention on body composition in adult patients with overweight or obesity].

197 overweight or obese patients were analyzed to compare the effects of intensified lifestyle intervention versus glucagon-like peptide-1 receptor agonist (GLP-1RA) combined with lifestyle intervention on body composition.

• The GLP-1RA combined with lifestyle intervention group experienced greater reductions in body weight (7.8 kg vs. 5.1 kg) and fat-free mass (2.2 kg vs. 1.0 kg) compared to the intensive lifestyle intervention group after 12 weeks.
• After 24 weeks, both groups showed significant decreases in body weight, body mass index (BMI), body fat percentage, fat mass, fat-free mass, and related indexes compared to pre-weight-loss values.
• The intensive lifestyle intervention group achieved larger reductions in body fat percentage (5.8% vs. 3.9%), fat mass (8.9 kg vs. 7.0 kg), and fat mass index (3.1 kg/m vs. 2.4 kg/m) compared to the GLP-1RA group.
• The reductions in fat-free mass and fat-free mass index were less pronounced in the intensive lifestyle intervention group (1.5 kg and 0.5 kg/m) compared to the GLP-1RA group (2.8 kg and 0.9 kg/m).
• Intensive lifestyle intervention may help retain more lean body mass during weight loss treatment compared to GLP-1RA combined with lifestyle intervention.

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