Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

12-hr synchronized cell division cycles are observed in murine intestinal organoids linked to the circadian clock.

• Circadian rhythms in intestinal stem and progenitor cells show reduced amplitude, suggesting influence from differentiated cells.
• Intercellular signaling is indicated to play a role in coordinating the relationship between the circadian clock and cell division.
• WNT, secreted by Paneth cells, is identified as a critical component for linking the circadian clock and the cell cycle.
• The findings suggest a complex interaction between biological clocks and cell division that may extend across different organisms.

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