Differences between intermittent and continuous feeding in the first week

Intermittent feeding may activate autophagy, a process that clears intracellular damage.

• Less aggressive nutrient administration is clinically superior in acute critical illness.
• Nutrient restriction is associated with the activation of autophagy.
• Intermittent feeding is theorized to preserve circadian rhythm and increase protein synthesis.
• Current guidelines advise against intermittent feeding due to lack of demonstrated benefits and increased risk of diarrhea.
• Research on intermittent feeding in the ICU mainly focuses on gastrointestinal complications.

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