The role of gut bitter taste receptors in health and their complex links to metabolism

Intestinal bitter taste receptors (TAS2Rs) play a crucial role in regulating the release of hormones that influence appetite and energy balance.

• TAS2Rs detect bitter compounds and regulate hormones like glucagon-like peptide-1 (GLP-1).
• These receptors are linked to appetite, satiety, food intake, and energy balance.
• TAS2Rs may interact with other taste receptors in the gut, which could influence disease progression.
• Shared signaling pathways between TAS2Rs and other taste receptors may facilitate this interaction.
• Factors such as genetics, gut microbiota, age, and sex can influence TAS2R expression.
• External chemicals can also alter TAS2R expression, potentially contributing to metabolic disorders.

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