Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms

Intestinal glucagon-like peptide-1 (GLP-1) is recognized as an endogenous satiation signal.

• GLP-1's effects on eating are primarily mediated by vagal nerve pathways.
• Recent findings challenge the idea that GLP-1 acts solely through nearby cells (paracrine action).
• A new model suggests that GLP-1 influences appetite through two distinct subsets of vagal afferents.
• The central mechanisms that process signals from these vagal pathways require further investigation.
• There is a possibility that GLP-1 secretion and its effects on eating are altered in obesity, which may contribute to obesity development.

AI simplified