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The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1
The liver-related vagus nerve branch is not needed for glucagon-like-peptide-1 to reduce blood sugar and food intake
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Abstract
Systemic GLP-1R mediation of glycemic control and food intake suppression involves paracrine signaling on vagal afferent fibers rather than requiring the common hepatic branch.
- Activation of GLP-1 receptors on vagal afferent fibers is linked to signaling that promotes feelings of fullness and enhances insulin secretion.
- Selective ablation of the common hepatic branch did not prevent increases in blood glucose after GLP-1 receptor blockade, suggesting its non-essential role in glycemic control.
- Complete vagal deafferentation resulted in a diminished incretin response, indicating the importance of vagal afferents in mediating GLP-1's effects.
- Both selective common hepatic branch ablation and control rats exhibited similar suppression of glucose intake following GLP-1 administration, while this effect was reduced in vagally deafferented rats.
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