Circulating Glucagon-like Peptide-1 (GLP-1) Inhibits Eating in Male Rats by Acting in the Hindbrain and Without Inducing Avoidance

Intrameal hepatic portal vein GLP-1 infusion reduced meal size by almost 40%.

• Intra-fourth ventricular infusion of the GLP-1 receptor antagonist exendin-9 did not affect eating directly but diminished the meal-inhibiting effect of HPV GLP-1.
• Lesions in the area postrema blocked the eating-inhibitory effect of HPV GLP-1.
• Pairing flavored saccharin solutions with HPV GLP-1 infusion did not change flavor acceptance, suggesting GLP-1 can inhibit eating without causing discomfort.
• A regular chow meal resulted in a transient increase in active GLP-1 levels in the hepatic portal vein but not in the vena cava.
• HPV GLP-1 infusion led to a significant temporary increase in GLP-1 concentration in the vena cava shortly after infusion.

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