Hepatic‐Portal Vein Infusions of Glucagon‐Like Peptide‐1 Reduce Meal Size and Increase c‐Fos Expression in the Nucleus Tractus Solitarii, Area Postrema and Central Nucleus of the Amygdala in Rats

Mar 20, 2010Journal of neuroendocrinology

Glucagon-like peptide-1 delivered to the liver area reduces meal size and activates brain regions controlling appetite in rats

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Abstract

GLP-1 infusion reduced meal size in rats by P < 0.05.

Remotely triggered infusions of GLP-1 decreased the size of the first nocturnal meal after a period of food deprivation.
The satiety ratio of meals increased with GLP-1 administration.
GLP-1 infusions led to increased c-Fos expression in specific brain regions associated with eating regulation.
The nucleus tractus solitarii, area postrema, and central nucleus of the amygdala may be involved in GLP-1's effects on meal size.
No significant changes in c-Fos expression were observed in the arcuate or paraventricular hypothalamic nuclei.

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We recently reported that brief, remotely controlled intrameal hepatic-portal vein infusions of glucagon-like peptide-1 (GLP-1) reduced spontaneous meal size in rats. To investigate the neurobehavioural correlates of this effect, we equipped male Sprague-Dawley rats with hepatic-portal vein catheters and assessed (i) the effect on eating of remotely triggered infusions of GLP-1 (1 nmol/kg, 5 min) or vehicle during the first nocturnal meal after 3 h of food deprivation and (ii) the effect of identical infusions performed at dark onset on c-Fos expression in several brain areas involved in the control of eating. GLP-1 reduced (P < 0.05) the size of the first nocturnal meal and increased its satiety ratio. Also, GLP-1 increased (P < 0.05) the number of c-Fos-expressing cells in the nucleus tractus solitarii, the area postrema and the central nucleus of the amygdala, but not in the arcuate or paraventricular hypothalamic nuclei. These data suggest that the nucleus tractus solitarii, the area postrema and the central nucleus of the amygdala play a role in the eating-inhibitory actions of GLP-1 infused into the hepatic-portal vein; it remains to be established whether activation of these brain nuclei reflect satiation, aversion, or both.

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Hepatic‐Portal Vein Infusions of Glucagon‐Like Peptide‐1 Reduce Meal Size and Increase c‐Fos Expression in the Nucleus Tractus Solitarii, Area Postrema and Central Nucleus of the Amygdala in Rats

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