Glucagon-like peptide-1 delivered to the liver area reduces meal size and activates brain regions controlling appetite in rats

GLP-1 infusion reduced meal size in rats by P < 0.05.

• Remotely triggered infusions of GLP-1 decreased the size of the first nocturnal meal after a period of food deprivation.
• The satiety ratio of meals increased with GLP-1 administration.
• GLP-1 infusions led to increased c-Fos expression in specific brain regions associated with eating regulation.
• The nucleus tractus solitarii, area postrema, and central nucleus of the amygdala may be involved in GLP-1's effects on meal size.
• No significant changes in c-Fos expression were observed in the arcuate or paraventricular hypothalamic nuclei.

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