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Intrameal Hepatic Portal and Intraperitoneal Infusions of Glucagon-Like Peptide-1 Reduce Spontaneous Meal Size in the Rat via Different Mechanisms
Glucagon-like peptide-1 given to the liver area or belly reduces meal size in rats through different ways
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Abstract
Hepatic portal vein infusion of 1.0 or 3.0 nmol/kg GLP-1 reduced meal size in rats without affecting subsequent eating behavior.
- Peripheral administration of GLP-1 is linked to reduced food intake during ongoing meals.
- Infusions of GLP-1 at specific doses (1.0 and 3.0 nmol/kg) decreased meal size compared to a control without altering the interval before the next meal.
- The reduction in meal size was consistent across different infusion sites, including the hepatic portal vein and vena cava.
- The satiating effect of intraperitoneal GLP-1 requires vagal nerve signaling, while intravenous GLP-1 may act directly on the brain.
- Rats with vagal nerve deafferentation showed different responses to GLP-1 based on the infusion route.
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