Peripheral Glucagon-like Peptide-1 (GLP-1) and Satiation

Mar 5, 2011Physiology & behavior

How the hormone GLP-1 outside the brain helps control feeling full

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Abstract

Data indicate that remotely controlled GLP-1 infusions selectively reduce meal size in chow-fed rats.

Intra-meal intravenous or intraperitoneal GLP-1 infusions are associated with a reduction in meal size.
Activation of GLP-1 receptors in the hindbrain is involved in the eating-inhibitory effects of intravenously infused GLP-1.
Intact abdominal vagal nerves are necessary for the eating-inhibitory effect of intraperitoneally infused GLP-1.
GLP-1 degradation in the liver may prevent increases in endogenous GLP-1 during normal eating.
Peripheral or hindbrain GLP-1 receptor antagonism does not appear to affect spontaneous eating.
Findings suggest that systemic increases in endogenous GLP-1 may not play a role in satiation in chow-fed rats.

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Peripheral GLP-1 is produced by post-translational processing of pro-glucagon in enteroendocrine L-cells and is released in response to luminal nutrient (primarily carbohydrate and fat) stimulation. GLP-1 is well known for its potent insulinotropic and gluco-regulatory effects. GLP-1 receptors (GLP-1R) are expressed in the periphery and in several brain areas that are implicated in the control of eating. Both central and peripheral administration of GLP-1 have been shown to reduce food intake. Unresolved, however, is whether these effects reflect functions of endogenous GLP-1. Data collected in our laboratory indicate that in chow-fed rats: 1) Remotely controlled, intra-meal intravenous (IV) or intraperitoneal (IP) GLP-1 infusions selectively reduce meal size; 2) hindbrain GLP-1R activation is involved in the eating-inhibitory effect of IV infused GLP-1, whereas intact abdominal vagal afferents are necessary for the eating-inhibitory effect of IP, but not IV, infused GLP-1; 3) GLP-1 degradation in the liver prevents a systemic increase in endogenous GLP-1 during normal chow meals in rats; and 4) peripheral or hindbrain GLP-1R antagonism by exendin-9 does not affect spontaneous eating. Also, although our data indicate that peripheral GLP-1 can act in two different sites to inhibit eating, they argue against a role of systemic increases in endogenous GLP-1 in satiation in chow-fed rats. Therefore, further studies should examine whether a local paracrine action of GLP-1 in the intestine or and endocrine action in the hepatic-portal area is physiologically relevant for satiation.

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Peripheral Glucagon-like Peptide-1 (GLP-1) and Satiation

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