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The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors
How glucagon-like peptide-1 signals in the brain's reward area reduce food intake through AMPA/kainate receptors
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Abstract
Intra-VTA injections of the GLP-1R agonist exendin-4 (Ex-4) reduced palatable high-fat food intake in rats primarily by reducing meal size.
- GLP-1 receptor activation in the ventral tegmental area is linked to decreased food intake.
- The reduction in meal size is associated with glutamatergic signaling involving AMPA/kainate receptors, but not NMDA receptors.
- GLP-1 receptors within the VTA may play a role in the effects of systemically administered Ex-4 on food intake and body weight.
- Ex-4 administration led to a rapid increase in tyrosine hydroxylase levels in the VTA, indicating modulation of dopaminergic signaling.
- Electrophysiological data showed increased frequency of AMPA-mediated currents in VTA dopamine neurons after Ex-4 treatment.
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