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GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake
GLP-1 neurons in the brainstem send signals to reward areas to regulate eating
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Abstract
Central GLP-1 receptor activation is associated with decreased food intake and body weight.
- GLP-1-producing neurons in the hindbrain project to the ventral tegmental area (VTA) and nucleus accumbens (NAc).
- Activation of GLP-1 receptors in the VTA, NAc core, and NAc shell is linked to reduced consumption of highly-palatable foods.
- Blocking GLP-1 receptor signaling in the VTA and NAc core leads to a significant increase in food intake.
- These findings suggest that the mesolimbic reward system is involved in GLP-1-mediated control of food intake and body weight.
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