Scientific reportsNov 6, 2025

Experiences of first-time users of inhaled 5-MeO-DMT

Psychedelic Science Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Jun 28, 2026

Abstract

Essence

Intranasal 5-MeO-DMT in psychedelic-naive healthy adults produced a short, intense experience with limited visual effects and prominent emotional, bodily, and insight-related content.

Evidence

This qualitative study nested within a double-blind, randomized, placebo-controlled phase 1 trial interviewed 32 healthy participants and found onset peaking at 8-15 minutes with return to baseline over 45-60 minutes, with intensity rising by dose and general tolerability.

Caveat

The findings are based on 32 healthy phase 1 participants and describe subjective phenomenology, not therapeutic outcomes or clinical efficacy.

Simplified

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic tryptamine. Plants containing 5-MeO-DMT have been used throughout history, and in recent years both synthetic and toad-derived 5-MeO-DMT use is being increasingly reported in naturalistic settings as well as clinical research. However, its subjective effects are not well characterised, and no qualitative research studies have been published to date. In this study, 32 psychedelic-naïve healthy participants from a double-blind, randomised, placebo-controlled, phase 1 trial of the escalating doses of a proprietary formulation of intranasal 5-MeO-DMT (BPL-003) were interviewed using the method shortly after dosing sessions. Microphenomenology is a qualitative research method well-suited to elucidating how subjective effects of this short-acting psychedelic unfold over time. Detailed qualitative and quantitative analysis of interview transcripts revealed a generic time-course of subjective effects, with rapid onset peaking at 8-15 min and gradual return to baseline over 45-60 min. The overall intensity of effects increased with dose and the doses tested were generally well tolerated. 5-MeO-DMT has a distinctive profile of subjective effects relative to published reports of other psychedelics, with a short duration of action, relative lack of visual effects, strong emotional or bodily experiences and the potential to elicit therapeutically relevant content, such as emotional breakthroughs and personal insights. These findings inform therapeutic applications, participant preparation, and future research on 5-MeO-DMT.

Key numbers

8–15 min

Peak Effect Timing

Time to peak subjective effects after intranasal administration.

45–60 min

Duration of Effects

Time taken for effects to return to baseline after peak.

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Experiences of first-time users of inhaled 5-MeO-DMT

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