Molecular vision

Eye injection of kainic acid does not stop daily rhythms of a key enzyme’s gene in rat light-sensing cells

Circadian Biology Weekly Brief ↗PubMed ↗

Updated

Abstract

Intraocular injections of kainic acid reduced Per2 mRNA levels by 20-50% in rat retinas.

  • Melatonin synthesis in retinal photoreceptors is under photic and circadian control.
  • KA injections did not abolish the daily rhythms of Aanat mRNA but shifted its phase in constant darkness.
  • KA treatment reduced mwl and swl opsin transcript levels and eliminated their daily rhythms, while rhodopsin mRNA levels remained unaffected.
  • Per1 and Per2 mRNA levels were rhythmically transcribed in both saline and KA-treated retinas.
  • Dopamine rhythmicity is not required for the circadian rhythm of Aanat mRNA in photoreceptors.

Simplified

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