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Intrinsically photosensitive retinal ganglion cells
Light-sensitive eye cells: types, roles, and medical importance
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Abstract
New insights into intrinsically photosensitive retinal ganglion cells (ipRGCs) highlight their diverse functions beyond vision.
- Several anatomically and functionally distinct subtypes of ipRGCs have been identified and characterized.
- ipRGCs play a significant role in nonvisual biological functions, such as the pupil light reflex and circadian photoentrainment.
- Recent evidence suggests ipRGCs may have an accessory role in the human visual system.
- The melanopsin system, associated with ipRGCs, has widespread clinical implications, particularly in the field of chronobiology.
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