Therapeutic Strategies for Ischemic Stroke: Modulating the Adult Neural Stem Cell Niche through the Wnt/β-catenin Pathway

Jul 31, 2024Journal of integrative neuroscience

Treating Stroke by Changing the Adult Brain Stem Cell Environment Using the Wnt/β-catenin Pathway

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Abstract

Ischemic stroke accounts for approximately 80% of stroke cases globally.

Ischemic stroke results from the blockage of blood vessels in the brain.
Enhancing the generation of new neurons may help replace damaged cells in the brain after a stroke.
The Wnt/β-catenin pathway has been shown to promote the creation of new neurons following brain injury.
Targeting the Wnt/β-catenin pathway could be a beneficial strategy for treating ischemic stroke and related neurological conditions.
This review discusses the role of the Wnt/β-catenin pathway in neurogenesis as a potential therapeutic approach.

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Stroke is a prominent contributor to mortality and impairment on a global scale. Ischemic stroke accounts for approximately 80% of stroke cases and is caused by occlusion of cerebral blood vessels. Enhancing neurogenesis through the modulation of the neural stem cell niche in the adult brain is a promising therapeutic strategy for individuals afflicted with ischemic stroke. Neurogenesis results in the generation of newborn neurons that serve as replacements for deceased neural cells within the ischemic core, thereby playing a significant role in the process of neural restoration subsequent to cerebral ischemia. Research has shown that activation of the Wnt/β-catenin pathway can augment neurogenesis following cerebral ischemia, suggesting that this pathway is a potentially beneficial therapeutic target for managing ischemic stroke. This review provides an extensive analysis of the current knowledge regarding the involvement of the Wnt/β-catenin pathway in promoting neurogenesis, thereby offering a promising avenue for therapeutic intervention in the context of ischemic stroke or other neurological impairments.

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