Time-restricted eating with equal calories changes daily body clocks but may not improve heart and metabolism health in overweight women

Two weeks of early or late time-restricted eating shifted circadian timing but did not improve insulin sensitivity or other cardiometabolic measures in women with overweight.

Randomized crossover trial in 31 women with overweight or obesity compared 2-week early versus late 8-hour eating windows under intended isocaloric conditions and found no meaningful between- or within-intervention changes in insulin sensitivity, 24-hour glucose, lipids, inflammatory markers, or oxidative stress markers, despite later monocyte and sleep timing with late TRE.

The evidence is short-term and small, and the intended isocaloric design still had minor calorie deficit and weight loss, which limits broader conclusions about longer-term TRE effects.