History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

Apr 5, 2017Journal of the National Cancer Institute

Having a history of common skin cancer and the risk of melanoma over time

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

A personal history of keratinocyte carcinoma is associated with a 2.22-fold increased risk of developing invasive melanoma.

1,949 cases of melanoma were documented over 6.4 million person-years of follow-up.
The risk of melanoma is greater for individuals with a history of both basal cell carcinoma and squamous cell carcinoma, with a hazard ratio of 3.40.
A history of basal cell carcinoma alone is associated with a hazard ratio of 2.20 for melanoma, while squamous cell carcinoma alone has a hazard ratio of 1.56.
There is a significant trend indicating increased melanoma risk with a higher number of keratinocyte carcinomas removed by surgery.
In women, a history of keratinocyte carcinoma is particularly associated with a higher risk of head and neck melanomas, with a hazard ratio of 4.17.

AI simplified

BACKGROUND: The association between history of keratinocyte carcinoma (KC, also known as nonmelanoma skin cancer) and risk of developing invasive melanoma has not been assessed comprehensively using prospective data.

METHODS: We followed 91 846 women in the Nurses' Health Study (NHS; 1984-2010), 114 918 women in the NHSII (1989-2011), and 48 946 men in the Health Professionals Follow-up Study (1986-2010) for diagnoses of KC and melanoma biennially. Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) of melanoma associated with history of KC, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). All statistical tests were two-sided.

RESULTS: We documented 1949 melanomas, 38 842 BCCs, and 7462 SCCs over 6.4 million person-years of follow-up. After adjustment for other risk factors, a personal history of KC was associated with an increased risk of melanoma (meta-analysis HR = 2.22, 95% CI = 1.73 to 2.85). The association was more apparent among participants with a history of both BCC and SCC (HR = 3.40, 95% CI = 1.60 to 7.19) than among participants with a history of BCC only (HR = 2.20, 95% CI = 1.80 to 2.70) or SCC only (HR = 1.56, 95% CI = 0.98 to 2.46), and there was a strong risk-increasing trend associated with a higher number of reported KCs removed by surgery ( P trend < .001). In women, KC history was more strongly associated with head/neck melanomas (HR = 4.17, 95% CI = 2.77 to 6.27) than with trunk or limb melanomas (both HRs < 2.50, P heterogeneity = .04).

CONCLUSIONS: Our results provide novel insights for the relationship between KC history and risk of developing melanoma, which may be important for melanoma prevention.

Full Text

Full text is available at the source.

View full text ↗

History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief