Ketamine's potential to treat sudden muscle weakness in Narcolepsy Type 1: Evidence from a patient and mouse study

Intranasal ketamine reduced cataplexy duration by 76% in a mouse study.

• A 34-year-old man with narcolepsy type 1 saw significant cataplexy reduction while using morning intranasal ketamine.
• Symptoms returned upon stopping ketamine treatment, indicating a potential dependence on the medication for symptom control.
• In a crossover study involving orexin knockout mice, ketamine significantly decreased the time spent in cataplexy without disrupting normal sleep patterns.
• These findings point to ketamine as a possible option for managing cataplexy in narcolepsy type 1, highlighting the need for further clinical research.

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