Alternative body-size ketamine dosing formulas did not outperform actual body weight dosing in .
Evidence
This retrospective exploratory registry analysis recalculated short-term IV ketamine doses in 22 TRBD inpatients using lean body mass, ideal body weight, and formulas.
Caveat
The sample was small, naturalistic, and uncontrolled, so the dosing comparisons are preliminary.
Simplified
BACKGROUND: Intravenous ketamine is effective in (TRBD) with dosing typically based on actual body weight (ABW).
OBJECTIVE: This study examined whether alternative normalization formulas are associated with treatment response.
DESIGN: A retrospective exploratory analysis of a naturalistic registry for short-term ketamine use.
METHODS: A total of 22 TRBD inpatients received short-term intravenous ketamine. Doses were recalculated using the Boer and Devine formulas for lean body mass (LBM) and ideal body weight (IBW), and the Mosteller formula for (BSA). Calculated doses were compared with ABW dosing in responders and nonresponders.
RESULTS: Using the Mosteller formula, BSA-normalized doses ranged from 17.63-23.09 mg/min nonresponders and 15.73-23.89 mg/min responders. LBM- and IBW-based recalculations at 0.5 mg/kg yielded lower relative doses, particularly among nonresponders, suggesting potential underdosing. 2 2
CONCLUSION: These preliminary findings do not support alternative dosing formulas over ABW, but replication in larger controlled studies is warranted.
Key numbers
17.63 mg/min to 23.09 mg/min
Dose Range for
Calculated doses using the Mosteller formula for .
15.73 mg/min to 23.89 mg/min
Dose Range for
Calculated doses using the Mosteller formula for .
22 patients
Patient Cohort Size
Total number of patients experiencing depressive episodes in this analysis.
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