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The ketamine metabolite (2R,6R)‐hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease
(2R,6R)-hydroxynorketamine, a ketamine breakdown product, restores protein production, brain cell connections, and memory in mouse models of Alzheimer's disease
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Abstract
HNK treatment may improve memory and synaptic function in Alzheimer's disease models.
- HNK activates important signaling pathways (ERK, mTOR, S6) in the hippocampus.
- In amyloid-β oligomer-infused mice, HNK rescues memory and synaptic function through ERK1/2 signaling.
- HNK also corrects transcription issues and memory deficits in aged APP/PS1 mice.
- These findings suggest that HNK could be a potential treatment for Alzheimer's disease.
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Key numbers
20%
Decrease in Protein Synthesis
Reduction in protein synthesis observed in hippocampal slices treated with .
0.5 mg/kg
Memory Deficits Reversed in
Dosing of administered to for memory recovery.