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Ketamine's Influence on Magnetoencephalography Patterns During a Working Memory Task in Treatment‐Resistant Depression: An Exploratory Study
Ketamine's effects on brain activity during a memory task in hard-to-treat depression
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Abstract
Ketamine administration resulted in increased gamma power in the parieto-occipital junction and decreased gamma power in the posterior superior temporal sulcus and inferior frontal gyrus.
- Ketamine significantly improved depressive symptoms in individuals with treatment-resistant depression (TRD).
- No improvement in cognitive performance, specifically working memory, attention, or concentration, was observed following ketamine administration.
- Distinct patterns of gamma power changes in brain regions associated with attention and working memory were noted after ketamine administration compared to placebo.
- Further exploration of the neurobiological mechanisms underlying ketamine's cognitive effects in TRD is warranted.
- Future studies are needed to investigate ketamine's cognitive effects using larger sample sizes and various cognitive assessments.
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