Neuropharmacology

Potassium channels in the brain's decision area may affect working memory in Parkinson's model rats

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Activation of M-channels in the lateral habenula improved working memory performance in rats with Parkinson's disease-related lesions.

  • Unilateral lesions in the substantia nigra compacta caused working memory impairment and increased firing rates of lateral habenula neurons.
  • Dopamine levels decreased in the ventral medial prefrontal cortex following substantia nigra compacta lesions.
  • Activating M-channels with retigabine enhanced working memory in both sham and lesioned rats, while blocking M-channels with XE-991 impaired it.
  • Higher doses of M-channel blockers were required to affect working memory in substantia nigra compacta-lesioned rats compared to sham-lesioned rats.
  • M-channel activation reduced firing rates of lateral habenula neurons and increased dopamine and serotonin release in the ventral medial prefrontal cortex.
  • The effects of M-channel modulation on neuron firing and neurotransmitter release were significantly shorter in substantia nigra compacta-lesioned rats.

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Competing interests

Declaration of competing interest All authors report no conflict of interest.
PubMed

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